2018-09-25 12:17:162025-05-22 12:35:08
title
yxjB
tlrB
description
unknown
23S rRNA (guanine-N(1)-)-methyltransferase, confers resistance against the macrolide antibiotic tylosin (produced by Streptomyces fradiae)
locus
BSU39010
BSU_39010
geneLength
846
849
function
unknown
resistance against tylosin
product
unknown
23S rRNA (guanine-N(1)-)-methyltransferase
ec
names
yxjB
tlrB
yxjB
outlinks
bsu
BSU39010
BSU_39010
Gene
Coordinates
4,004,288 → 4,005,136
4,004,288 4,005,136
Biological materials
Mutant
MGNA-B726 (yxjB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1725 NBRP B. subtilis, Japan]
1A995 ( ''yxjB''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A995&Search=1A995 BGSC]
BKE39010 (Δ[[gene|tlrB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATAAAAAACACCCCAT, downstream forward: _UP4_TGAATGGTAGAGGAAAGCTC
BKK39010 (Δ[[gene|tlrB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATAAAAAACACCCCAT, downstream forward: _UP4_TGAATGGTAGAGGAAAGCTC
MGNA-B726 (yxjB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1725 NBRP B. subtilis, Japan]
1A995 ( ''yxjB''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A995&Search=1A995 BGSC]
BKE39010 ([[gene|tlrB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATAAAAAACACCCCAT, downstream forward: _UP4_TGAATGGTAGAGGAAAGCTC
BKK39010 ([[gene|tlrB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGATAAAAAACACCCCAT, downstream forward: _UP4_TGAATGGTAGAGGAAAGCTC
References
The protein
Catalyzed reaction/ biological activity
methylates G748 of 23S rRNA in the peptide exit tunnel [pubmed|31719185]
The protein
Protein family
[SW|Methyltransferase superfamily] (according to UniProt)
The protein
Paralogous protein(s)
[[this]]
The protein
Structure
[PDB|1P91] (from E. coli, 31% identity) [pubmed|14999102]